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Dezhe Z. Jin : Associative chain as the foundation for action sequence and timing: a case study with birdsong

  -   Nonlinear and Complex Systems ( 138 Views )

Sequence and timing are two fundamental aspects of many critical motor actions that humans and animals must learn and perform. Human speech is a familiar example. How precisely timed action sequences are controlled by networks of neurons, and how such neural networks form through experience, are poorly understood.

Songbirds are excellent animal models for investigating these problems. Male songbirds learn to sing songs with exquisite temporal complexity and precision, similar to human speech. Unlike human brains, songbird brains are experimentally accessible. Indeed, the wealth of experimental data on songbirds makes them ideal systems for computational modeling.

In this talk, I will present a computational study of production and learning of timed action sequence, using birdsong as a concrete example. First, I will advance the idea that associative chains of neurons, also called "synfire chains" in some context, are fundamental building blocks of sequence generating networks. I will show experimental evidence of their existence in the songbird brain, including the recent discovery of a critical property of song controlling neurons, which was predicted by a computational analysis of the robustness of the associative chain dynamics against imperfects in the connectivity and other sources of noise. Second, I will demonstrate computationally that associative chains can form simply through a self-organized process, which depends on ubiquitously observed properties of neurons, including spike-time dependent plasticity of synapses, axonal remodeling, and spontaneous activity. This result suggests that associative chains are stable "attractors" of neural connectivity. The process is robust against death and renewal of neurons, which naturally occur in songbird brain. Finally, I will illustrate that associative chains are also useful for sequence recognition tasks, such as song recognition in songbirds, thus can serve as the neural substrate of sensory-motor integration.

Henry Greenside (hsg@phy.duke.edu) will be the host for his visit.