## Curtis Porter : CRash CouRse in CR Geometry

- Graduate/Faculty Seminar,Uploaded Videos ( 2109 Views )CR geometry studies real hypersurfaces in complex vector spaces and their generalizations, CR manifolds. In many cases of interest to complex analysis and PDE, CR manifolds can be considered ``curved versions" of homogeneous spaces according to Elie Cartan’s generalization of Klein’s Erlangen program. Which homogeneous space is the ``flat model" of a CR manifold depends on the Levi form, a tensor named after a mathematician who used it to characterize boundaries of pseudoconvex domains. As in the analytic setting, the Levi form plays a central role in the geometry of CR manifolds, which we explore in relation to their homogeneous models.

## Haotian Gu : Universality and Phase Transitions of Holomorphic Multiplicative Chaos

- Probability ( 7 Views )The random distribution Holomorphic multiplicative chaos (HMC) with Gaussian inputs is recently introduced independently by Najnudel, Paquette, and Simm as a limiting object on the unit complex circle of characteristic polynomial of circular beta ensembles, and by Soundararajan and Zaman as an analogue of random multiplicative functions. In this talk, we will explore this rich connection between HMC and random matrix theory, number theory, and Gaussian multiplicative chaos. We will also discuss the regularity of this distribution, alongside the fractional moments and tightness of its Fourier coefficients (also referred to as secular coefficients). Furthermore, we introduce non-Gaussian HMC, and discuss the Gaussian universality and two phase transitions phenomenon in the fractional moments of its secular coefficients. A transition from global to local effect is observed, alongside an analysis of the critical local-global case. As a result, we unveil the regularity of some non-Gaussian HMC and tightness of their secular coefficients. Based on joint work with Zhenyuan Zhang.

## Vakhtang Poutkaradze : Lie-Poisson Neural Networks (LPNets): Data-Based Computing of Hamiltonian Systems with Symmetries

- Applied Math and Analysis ( 13 Views )Physics-Informed Neural Networks (PINNs) have received much attention recently due to their potential for high-performance computations for complex physical systems, including data-based computing, systems with unknown parameters, and others. The idea of PINNs is to approximate the equations and boundary and initial conditions through a loss function for a neural network. PINNs combine the efficiency of data-based prediction with the accuracy and insights provided by the physical models. However, applications of these methods to predict the long-term evolution of systems with little friction, such as many systems encountered in space exploration, oceanography/climate, and many other fields, need extra care as the errors tend to accumulate, and the results may quickly become unreliable. We provide a solution to the problem of data-based computation of Hamiltonian systems utilizing symmetry methods. Many Hamiltonian systems with symmetry can be written as a Lie-Poisson system, where the underlying symmetry defines the Poisson bracket. For data-based computing of such systems, we design the Lie-Poisson neural networks (LPNets). We consider the Poisson bracket structure primary and require it to be satisfied exactly, whereas the Hamiltonian, only known from physics, can be satisfied approximately. By design, the method preserves all special integrals of the bracket (Casimirs) to machine precision. LPNets yield an efficient and promising computational method for many particular cases, such as rigid body or satellite motion (the case of SO(3) group), Kirchhoff's equations for an underwater vehicle (SE(3) group), and others. Joint work with Chris Eldred (Sandia National Lab), Francois Gay-Balmaz (CNRS and ENS, France), and Sophia Huraka (U Alberta). The work was partially supported by an NSERC Discovery grant.

## Manon Michel : Non-reversible Markov processes in particle systems

- Probability ( 19 Views )Recently, Markov-chain Monte Carlo methods based on non-reversible piecewise deterministic Markov processes (PDMP) are under growing attention, thanks to the increase in performance they usually bring. Beyond their numerical efficacy, the non-reversible and piecewise deterministic characteristics of these processes prompt interesting questions, regarding for instance ergodicity proof and convergence bounds. During this talk, I will particularly focus on the obtained results and open problems left while considering PDMP evolution of particle systems, both in an equilibrium and out-of-equilibrium setting. Hardcore particle systems have embodied a testbed of choice since the first implementations of Markov chain Monte Carlo in the 50’s. Even today, the entropic barriers they exhibit are still resisting to the state-of-the-art MCMC sampling methods. During this talk, I will review the recent developments regarding sampling such systems and discuss the dynamical bottlenecks that are yet to be solved.

## Chen Wan : A local twisted trace formula for some spherical varieties

- Number Theory ( 15 Views )In this talk, I will discuss the geometric expansion of a local twisted trace formula for some special varieties. This generalizes the local (twisted) trace formula for reductive groups proved by Arthur and Waldspurger. By applying the trace formula, we prove a multiplicity formula for these spherical varieties. And I will also discuss some applications to the multiplicity of the Galois model and the unitary Shalika model. This is a joint work with Raphael Beuzart-Plessis.

## Dean Bottino : Evaluating Strategies for Overcoming Rituximab (R) Resistance Using a Quantitative Systems Pharmacology (QSP) model of Antibody-Dependent Cell-mediated Cytotoxicity & Phagocytosis (ADCC & ADCP): An Academic/Industrial Collaboration

- Mathematical Biology ( 37 Views )Despite the impressive performance of rituximab (R) containing regimens like R-CHOP in CD20+ Non-Hodgkin’s Lymphoma (NHL), 30-60% of R-naïve NHL patients are estimated to be resistant, and approximately 60% of those patients will not respond to subsequent single agent R treatment. Given that antibody dependent cell mediated cytotoxicity (ADCC) and phagocytosis (ADCP) are thought to be the major mechanisms of action of Rituximab, increasing the activation levels of natural killer (NK) and macrophage (MP) cells may be one strategy for overcoming R resistance.

During (and after) the Fields Institute Industrial Problem Solving Workshop in August 2019, academic participants and industry mentors developed and calibrated to literature data a quantitative systems pharmacology (QSP) model of ADCC/ADCP to interrogate which mechanisms of R resistance could be overcome by increased NK or MP activation, and how much effector cell activation would be required to overcome a given degree and mechanism of R resistance.

This work was motivated by a real-world pharmaceutical drug development question, and the academic-industry interactions during and after the workshop resulted in sharknado plots as well as a published QSP model (presented at American Association of Cancer Research Annual Meeting, 2021) that was able to address some of the key questions around overcoming R resistance. The published model was then incorporated into an in-house QSP model supporting the development of a Takeda investigational drug which is being developed to restore R sensitivity in an R-resistant patient population.

## Duncan Dauvergne : Geodesic networks in random geometry

- Presentations ( 19 Views )The directed landscape is a random directed metric on the plane that is the scaling limit for models in the KPZ universality class. In this metric, typical pairs of points are connected by a unique geodesic. However, certain exceptional pairs are connected by more exotic geodesic networks. The goal of this talk is to describe a full classification for these exceptional pairs. I will also discuss some connections with other models of random geometry.

## Farid Hosseinijafari : On the Special Values of Certain L-functions: G_2 over a Totally Imaginary Field

- Number Theory ( 48 Views )In this talk, I will present an overview of the framework originally proposed by Harder and further developed in collaboration with Raghuram to address rationality problems for special values of certain automorphic L-functions. I will then proceed to state my main results on the rationality of the special values of Langlands-Shahidi L-functions appearing in the constant term of the Eisenstein series associated with the exceptional group of type G_2 over a totally imaginary number field. This study marks the first instance where rank-one Eisenstein cohomology is employed to investigate the arithmetic of automorphic L-functions in the presence of multiple L-functions.

## Duncan Dauvergne : Random planar geometry and the Kardar-Parisi-Zhang universality class

- Presentations ( 24 Views )Consider the lattice Z^2, and assign length 1 or 2 to every edge by flipping a series of independent fair coins. This gives a random weighted graph, and looking at distances in this graph gives a random planar metric. This model is expected to have a continuum scaling limit as we decrease the spacing between lattice points. Moreover, most natural models of random planar metrics and random interface growth (the so-called `KPZ universality class') are expected to converge to the same limiting geometry. The goal of this talk is to introduce this limit, known as the directed landscape, and describe at least one model where we can actually prove convergence.

## Lenny Ng : New algebraic invariants of Legendrian links

- Geometry and Topology ( 29 Views )For the past 25 years, a key player in contact topology has been the Floer-theoretic invariant called Legendrian contact homology. I'll discuss a package of new invariants for Legendrian knots and links that builds on Legendrian contact homology and is derived from rational symplectic field theory. This includes a Poisson bracket on Legendrian contact homology and a symplectic structure on augmentation varieties. Time permitting, I'll also describe an unexpected connection to cluster theory for a family of Legendrian links associated to positive braids. Parts of this are joint work in progress with Roger Casals, Honghao Gao, Linhui Shen, and Daping Weng.

## Anna Skorobogatova : Area-minimizing currents: structure of singularities and uniqueness of tangent cones

- Geometry and Topology ( 35 Views )The problem of determining the size and structure of the interior singular set of area-minimizing surfaces has been studied thoroughly in a number of different frameworks, with many ground-breaking contributions. In the framework of integral currents, when the surface has higher codimension than 1, the presence of singular points with flat tangent cones creates an obstruction to easily understanding the interior singularities. Until recently, little was known in this direction, particularly for surfaces of dimension higher than two, beyond Almgren’s celebrated dimension estimate on the interior singular set. In this talk I will discuss joint works with Camillo De Lellis and Paul Minter, where we establish (m-2)-rectifiability of the interior singular set of an m-dimensional area-minimizing integral current and classify tangent cones at \mathcal{H}^{m-2}-a.e. interior point.

## Chun-Hsien Hsu : Weyl algebras on certain singular affine varieties

- Number Theory ( 51 Views )The module theory of the Weyl algebra, known as the theory of $D$-modules, has profound applications in various fields. One of the most famous results is the Riemann-Hilbert correspondence, establishing equivalence between holonomic $D$-modules and perverse sheaves on smooth complex varieties. However, when dealing with singular varieties, such correspondence breaks down due to the non-simplicity of Weyl algebras on singular varieties. In our ongoing work, we introduce a new ring of differential operators on certain singular affine varieties, whose definition is analytically derived from harmonic analysis. It should contain the Weyl algebra as a proper subring and shares many properties with the Weyl algebra on smooth varieties. In the talk, after a brief review of the Weyl algebra, I will explain how the new ring of differential operators arises as a consequence of an explicit form of the Poisson summation conjecture and discuss its properties.

## Brian Wecht : Towards a c-theorem in Four Dimensions

- String Theory ( 13 Views )Intuitively, renormalization group flow is irreversible, since one would expect the number of massless degrees of freedom of a theory to decrease as one goes to progressively larger distance scales. This has been proven rigorously in two dimensions (the "c-theorem"), but is otherwise an open problem. I will discuss recent efforts to prove an analogous theorem in four dimensions for supersymmetric theories, for which we can make exact statements not usually accessible in their non-supersymmetric counterparts.

## Marcel Vonk : Topological Strings, Black Holes and Matrix Models

- String Theory ( 14 Views )It is known that many random matrix models have a dual description in terms of a topological string theory. Moreover, recently, Ooguri, Strominger and Vafa have shown that one can calculate certain properties of N=2 supersymmetric black holes in four dimensions using a topological string theory. In this talk, based on hep-th/0410141, I connect these two developments, and discuss what matrix models can teach us about black holes.

## Angel Uranga : Brane Configurations and Branes at Singularities

- String Theory ( 11 Views )The dynamics of D branes moving in certain string theory backgrounds can be used to learn about supersymmetric field theories in several dimensions. In this talk I will center on the realization of four-dimensional N=2 and N=1 gauge field theories, by using two types of backgrounds. The first (`brane configurations') involves D branes in the presence of NS fivebranes, whereas the second involves D branes sitting at singular points. A wide variety of conformal theories with marginal couplings, and of finite N=1 theories arises from these constructions. I will also emphasize the equivalence of different constructions by T duality.

## Washington Taylor : Counting flux vacua with special properties

- String Theory ( 9 Views )I will discuss the statistical analysis of flux vacua with special properties such as (no-scale) supersymmetry and discrete symmetries. Unlike generic flux vacua, enumeration of such special vacua can require number-theoretic methods.