Quicklists
public 01:34:45

Jie Yu : TBA

  -   Nonlinear and Complex Systems ( 152 Views )

public 01:39:44

Katia Koelle : Exploration, innovation, and selective sweeps in the ecology

  -   Nonlinear and Complex Systems ( 140 Views )

For many biological systems, the timescale at which ecological interactions occur is much shorter than the timescale at which evolutionary changes occur. For rapidly evolving pathogens such as influenza, however, this is not the case; influenza researchers therefore need to understand both the ecological interactions between the host and the pathogen and the virus?s evolutionary changes in order to ultimately control the disease in humans. Recently, a study looking at the evolutionary patterns of influenza showed that, while the virus?s genetic evolution occurred gradually, its antigenic evolution occurred in a punctuated manner. (Genetic evolution refers to how the virus?s nucleotides change over time; antigenic evolution refers to how the virus changes over time with respect to how our immune system recognizes it.) Previous research from our group hypothesized that these differences in evolutionary patterns could be explained by the presence of /neutral networks/ in the virus?s genotype space: networks of sequences that differ genetically from one another but fold into the same protein conformation and thereby share antigenic properties. Here, I will present a simple epidemiological model that implicitly incorporates these neutral networks. I show that this model can reproduce (1) the seasonal and interannual outbreak patterns of influenza, (2) the quantitative patterns of influenza?s antigenic evolution, and (3) the patterns of the virus?s genetic evolution, including its characteristic phylogenetic tree. I end with how this model may be useful in understanding patterns of viral diversity in other host species (e.g., avian and equine hosts).

public 01:39:44

Bob Behringer : TBA

  -   Nonlinear and Complex Systems ( 142 Views )

public 01:34:44

Gaby Katul : TBA

  -   Nonlinear and Complex Systems ( 190 Views )

public 01:34:25

Paul Bendich : Job Tryout

  -   Graduate/Faculty Seminar ( 141 Views )

Another Job Audition.

public 01:34:27

Ezra Miller : Metric geometry and unfoldings of polyhedra

  -   Presentations ( 161 Views )

public 01:44:45