## Leo Darrigade : Modelling G protein-coupled receptors (GPCRs) compartmentalized signaling

- Mathematical Biology ( 21 Views )G protein-coupled receptors (GPCRs) are membrane receptors that play a pivotal role in the regulation of reproduction and behavior in humans. Upon binding to specific ligands, they trigger a local cAMP production. Activated receptor are then internalized to different endosomal compartments where they can continue signaling before being recycled or destroyed. Recent studies showed that the different pools of cAMP have different effect on the cell.

In the first part of the talk, I will present a piecewise deterministic Markov process (PDMP) of intracellular signaling. The stochastic part of the model accounts for formation, coagulation, fragmentation and recycling of intracellular vesicles which contain the receptor, whereas the deterministic part of the model represents evolution of chemical reactions due to signaling activity of the receptor. We are interested in the existence of and convergence to a stationary measure. I will present different cases for which we were able to obtain results in this direction.

In the second part of the talk, I will present the numerical workflow (SBML, PEtab and PyPESTO) we use to fit ODEs model of GPCR signaling to longitudinal measure of chemical concentrations (BRET data).

## Sanchit Chaturvedi : Phase mixing in astrophysical plasmas with an external Kepler potential

- Applied Math and Analysis ( 22 Views )In Newtonian gravity, a self-gravitating gas around a massive object such as a star or a planet is modeled via Vlasov Poisson equation with an external Kepler potential. The presence of this attractive potential allows for bounded trajectories along which the gas neither falls in towards the object or escape to infinity. We focus on this regime and prove first a linear phase mixing result in 3D outside symmetry with exact Kepler potential. Then we also prove a long-time nonlinear phase mixing result in spherical symmetry. The mechanism is phenomenologically similar to Landau damping on a torus but mathematically the situation is quite a lot more complex. This is based on an upcoming joint work with Jonathan Luk at Stanford.

## Louis Fostier : A model of oocyte population dynamics for fish oogenesis

- Mathematical Biology ( 27 Views )We introduce and analyze a size-structured oocyte population model, with non local nonlinearities on recruitment, growth and mortality rates to take into account interactions between cells. We pay special attention to the form of the recruitment term, and its influence on the asymptotic behavior of the cell population.

This model is well-suited for representing oocyte population dynamics within the fish ovary. The nonlocal nonlinearities enable us to capture the diverse feedback mechanisms acting on the growth of oocytes of varying sizes and on the recruitment of new oocytes.

We firstly investigate the existence and uniqueness of global bounded solutions by transforming the partial differential equation into an equivalent system of integral equations, which can be solved using the Contraction Mapping Principle.

In a second step, we investigate the asymptotic behavior of the model. Under an additional assumption regarding the form of the growth rate, we can, with the use of a classical time-scaling transformation, reduce the study to that of a equation with linear growth speed and nonlinear inflow boundary condition. Using arguments from the theory of abstract semilinear Cauchy problems, we investigate the local stability of stationary solutions of this equation by reducing it to a characteristic equation involving the eigenvalues of the linearized problem around equilibrium states.

When the mortality rate is zero, the study of existence and stability of stationary solutions is simplified. Explicit calculations can be carried out in certain interesting cases.

## Sean Lawley : Stochastics in medicine: Delaying menopause and missing drug doses

- Mathematical Biology ( 34 Views )Stochastic modeling and analysis can help answer pressing medical questions. In this talk, I will attempt to justify this claim by describing recent work on two problems in medicine. The first problem concerns ovarian tissue cryopreservation, which is a proven tool to preserve ovarian follicles prior to gonadotoxic treatments. Can this procedure be applied to healthy women to delay or eliminate menopause? How can it be optimized? The second problem concerns medication nonadherence. What should you do if you miss a dose of medication? How can physicians design dosing regimens that are robust to missed/late doses? I will describe (a) how stochastics theory offers insights into these questions and (b) the mathematical questions that emerge from this investigation. The first problem is based on joint work with Joshua Johnson (University of Colorado School of Medicine), John Emerson (Yale University), and Kutluk Oktay (Yale School of Medicine).

## Cheng Chen : Progresses of the local Gan-Gross-Prasad conjecture

- Number Theory ( 30 Views )The classical branching rules describe the spectrum of an irreducible complex representation of a compact Lie group to its subgroup. The local Gan–Gross–Prasad conjecture generalizes the branching problem to classical groups over local fields of characteristic zero. After the pioneering work of Waldspurger, there has been significant progress on the conjecture using various approaches. In my talk, I will introduce a relatively uniform approach to prove the conjecture, including joint work with Z. Luo and joint work with R. Chen and J. Zou.

## John Voight : Computing with Hilbert modular surfaces

- Number Theory ( 32 Views )Hilbert modular surfaces are 2-dimensional analogues of modular curves, parametrizing polarized abelian surfaces with endomorphism and level structure. Modular curves are stratified by genus, and canonical equations for modular curves are obtained from the graded ring of modular forms. Similar to how curves are stratified by genus, surfaces are organized by their numerical invariants; the Enriques-Kodaira classification organizes smooth surfaces by Kodaira dimension, Hodge numbers, and Chern numbers. In this talk, we explain how to compute these invariants and equations for certain Hilbert modular surfaces. This is joint work with Eran Assaf, Angie Babei, Ben Breen, Sara Chari, Edgar Costa, Juanita Duque-Rosero, Alex Horawa, Jean Kieffer, Avi Kulkarni, Grant Molnar, Abhijit S. Mudigonda, Michael Musty, Sam Schiavone, Shikhin Sethi, and Samuel Tripp.