## Zane Li : Interpreting a classical argument for Vinogradovs Mean Value Theorem into decoupling language

- Applied Math and Analysis ( 136 Views )There are two proofs of Vinogradov's Mean Value Theorem (VMVT), the harmonic analysis decoupling proof by Bourgain, Demeter, and Guth from 2015 and the number theoretic efficient congruencing proof by Wooley from 2017. While there has been some work illustrating the relation between these two methods, VMVT has been around since 1935. It is then natural to ask: What does previous partial progress on VMVT look like in harmonic analysis language? How similar or different does it look from current decoupling proofs? We talk about a classical argument due to Karatsuba that shows VMVT "asymptotically" and interpret this in decoupling language. This is joint work with Brian Cook, Kevin Hughes, Olivier Robert, Akshat Mudgal, and Po-Lam Yung.

## Ashvin Swaminathan : Geometry-of-numbers in the cusp, and class groups of orders in number fields

- Number Theory ( 96 Views )In this talk, we discuss the distributions of class groups of orders in number fields. We explain how studying such distributions is related to counting integral orbits having bounded invariants that lie inside the cusps of fundamental domains for coregular representations. We introduce two new methods to solve this counting problem, and as an application, we demonstrate how to determine the average size of the 2-torsion in the class groups of cubic orders. Much of this work is joint with Arul Shankar, Artane Siad, and Ila Varma.

## Kai Xu : pi_2-systolic inequalities for 3-manifolds with positive scalar curvature

- Geometry and Topology ( 88 Views )We discuss the following recent result of the speaker. Suppose a closed 3-manifold M has scalar curvature at least 1, and has nontrivial second homotopy group, and is not covered by the cylinder (S^2)*R. Then the pi_2-systole of M (i.e. the minimal area in the second homotopy group) is bounded by a constant that is approximately 5.44pi. If we include quotients of cylinder into consideration, then the best upper bound is weakened to 8_pi. This shows a topological gap in the pi_2-systolic inequality. We will discuss the ideas behind this theorem, as well as the proof using Huisken and Ilmanen’s weak inverse mean curvature flow.

## Chun-Hung Liu : Assouad-Nagata dimension of minor-closed metrics

- Mathematical Biology ( 81 Views )Assouad-Nagata dimension addresses both large-scale and small-scale behaviors of metric spaces and is a refinement of Gromov’s asymptotic dimension. A metric space is a minor-closed metric if it is defined by the distance function on the vertices of an edge-weighted graph that satisfies a fixed graph property preserved under vertex-deletion, edge-deletion, and edge-contraction. In this talk, we determine the Assouad-Nagata dimension of every minor-closed metric. It is a common generalization of known results about the asymptotic dimension of H-minor free unweighted graphs, about the Assouad-Nagata dimension of complete Riemannian surfaces with finite Euler genus, and about their corollaries on weak diameter coloring of minor-closed families of graphs and asymptotic dimension of minor-excluded groups.

## Leo Darrigade : Modelling G protein-coupled receptors (GPCRs) compartmentalized signaling

- Mathematical Biology ( 49 Views )G protein-coupled receptors (GPCRs) are membrane receptors that play a pivotal role in the regulation of reproduction and behavior in humans. Upon binding to specific ligands, they trigger a local cAMP production. Activated receptor are then internalized to different endosomal compartments where they can continue signaling before being recycled or destroyed. Recent studies showed that the different pools of cAMP have different effect on the cell.

In the first part of the talk, I will present a piecewise deterministic Markov process (PDMP) of intracellular signaling. The stochastic part of the model accounts for formation, coagulation, fragmentation and recycling of intracellular vesicles which contain the receptor, whereas the deterministic part of the model represents evolution of chemical reactions due to signaling activity of the receptor. We are interested in the existence of and convergence to a stationary measure. I will present different cases for which we were able to obtain results in this direction.

In the second part of the talk, I will present the numerical workflow (SBML, PEtab and PyPESTO) we use to fit ODEs model of GPCR signaling to longitudinal measure of chemical concentrations (BRET data).

## Vakhtang Poutkaradze : Lie-Poisson Neural Networks (LPNets): Data-Based Computing of Hamiltonian Systems with Symmetries

- Applied Math and Analysis ( 47 Views )Physics-Informed Neural Networks (PINNs) have received much attention recently due to their potential for high-performance computations for complex physical systems, including data-based computing, systems with unknown parameters, and others. The idea of PINNs is to approximate the equations and boundary and initial conditions through a loss function for a neural network. PINNs combine the efficiency of data-based prediction with the accuracy and insights provided by the physical models. However, applications of these methods to predict the long-term evolution of systems with little friction, such as many systems encountered in space exploration, oceanography/climate, and many other fields, need extra care as the errors tend to accumulate, and the results may quickly become unreliable. We provide a solution to the problem of data-based computation of Hamiltonian systems utilizing symmetry methods. Many Hamiltonian systems with symmetry can be written as a Lie-Poisson system, where the underlying symmetry defines the Poisson bracket. For data-based computing of such systems, we design the Lie-Poisson neural networks (LPNets). We consider the Poisson bracket structure primary and require it to be satisfied exactly, whereas the Hamiltonian, only known from physics, can be satisfied approximately. By design, the method preserves all special integrals of the bracket (Casimirs) to machine precision. LPNets yield an efficient and promising computational method for many particular cases, such as rigid body or satellite motion (the case of SO(3) group), Kirchhoff's equations for an underwater vehicle (SE(3) group), and others. Joint work with Chris Eldred (Sandia National Lab), Francois Gay-Balmaz (CNRS and ENS, France), and Sophia Huraka (U Alberta). The work was partially supported by an NSERC Discovery grant.