The problem of determining the size and structure of the interior singular set of area-minimizing surfaces has been studied thoroughly in a number of different frameworks, with many ground-breaking contributions. In the framework of integral currents, when the surface has higher codimension than 1, the presence of singular points with flat tangent cones creates an obstruction to easily understanding the interior singularities. Until recently, little was known in this direction, particularly for surfaces of dimension higher than two, beyond Almgren’s celebrated dimension estimate on the interior singular set. In this talk I will discuss joint works with Camillo De Lellis and Paul Minter, where we establish (m-2)-rectifiability of the interior singular set of an m-dimensional area-minimizing integral current and classify tangent cones at \mathcal{H}^{m-2}-a.e. interior point.

We'll give a useful description of braids in $\underset{n}{\#}(S^1\times S^2)$ using surgery diagrams, which will allow us to address families of knots in lens spaces that admit fillable positive contact surgery. We also demonstrate that smooth $16$ surgery to the knot $P(-2,3,7)$ bounds a rational ball, which admits a Stein handlebody. This answers a question left open by Thomas Mark and Bülent Tosun.

Studying symplectic structures up to deformation equivalences is a fundamental question in symplectic geometry. Donaldson asked: given two homeomorphic closed symplectic four-manifolds, are they diffeomorphic if and only if their stabilized symplectic six-manifolds, obtained by taking products with CP^1 with the standard symplectic form, are deformation equivalent? I will discuss joint work with Amanda Hirschi on showing how deformation inequivalent symplectic forms remain deformation inequivalent when stabilized, under certain algebraic conditions. This gives the first counterexamples to one direction of Donaldson’s “four-six” question and the related Stabilizing Conjecture by Ruan. In the other direction, I will also discuss more supporting evidence via Gromov-Witten invariants.

In this talk I will present a recent result showing that for all solutions of the 2d Euler equations with initial vorticity with finite Sobolev smoothness then an initial data dependent norm of the associated Lagrangian flow blows up in infinite time like $t^{\frac{1}{3}}$. This initial data dependent norm quantifies the exact $L^2$ decay of the Fourier transform of the solution. This adapted norm turns out to be the exact quantity that controls a low to high frequency cascade which I will then show to be the quantitative phenomenon behind a microlocal generalized Lyapunov function constructed by Shnirelman.

The categorical p-adic local Langlands correspondence has been established for the group GL_2(Q_p) in joint work of the speaker with Andrea Dotto and Toby Gee. In this talk I will describe some aspects of this categorical correspondence. I hope to indicate the relationship to existing ideas in the subject: particularly to Taylor--Wiles--Kisin patching, but also to the work of Colmez and Paskunas, and to recent work of Johansson--Newton--Wang-Erickson. But more than this, I hope to indicate some of the underlying philosophy of the correspondence: what it means to represent the category of representations of a group geometrically, and why stacks (rather than just varieties) play a key role.

The class number formula describes the behavior of the Dedekind zeta function at s = 0. The Stark conjecture extends the class number formula, describing the behavior of Artin L-functions at s = 0 in terms of units. The Harris–Venkatesh conjecture, originally motivated by the conjectures of Venkatesh and Prasanna–Venkatesh on derived Hecke algebras, can be viewed as an analogue to the Stark conjecture modulo p. In this talk, I will draw an introductory picture, formulate a unified conjecture combining Harris–Venkatesh and Stark for modular forms of weight 1, and describe the proof of this in the imaginary dihedral case. Time permitting, I will also describe some new questions and in-progress work modulo pn.

Ensembles of redistricting plans can be challenging to analyze and visualize because every plan is an unordered set of shapes, and therefore non-Euclidean in at least two ways. I will describe two methods designed to address this challenge: barycenters for partitioned datasets, and a novel dimension reduction technique based on Gromov-Wasserstein distance. I will cover some of the theory behind these methods and show how they can help us untangle redistricting ensembles to find underlying trends. This is joint work with Ranthony A. Clark and Tom Needham.

Surface Plasmon Resonance (SPR) assays are a standard approach for quantifying kinetic parameters in antibody-antigen binding reactions. Classical SPR approaches ignore the bivalent structure of antibodies, and use simplified ODE models to estimate effective reaction rates for such interactions. In this work we develop a new SPR protocol, coupling a model that explicitly accounts for the bivalent nature of such interactions and the limited spatial distance over which such interactions can occur, to a SPR assay that provides more features in the generated data. Our approach allows the estimation of bivalent binding kinetics and the spatial extent over which antibodies and antigens can interact, while also providing substantially more robust fits to experimental data compared to classical bivalent ODE models. I will present our new modeling and parameter estimation approach, and demonstrate how it is being used to study interactions between antibodies and spike protein. I will also explain how we make the overall parameter estimation problem computationally feasible via the construction of a surrogate approximation to the (computationally-expensive) particle model. The latter enables fitting of model parameters via standard optimization approaches.

Homogenization is the approximation of a complex, “disordered” system by a simpler, “ordered” one. Picture a walker on a grid. In each step, the walker chooses to walk along a neighboring edge with equal probability. At large scales, the walker approximates Brownian motion. But what if some edges are more likely to be traversed than others? I will discuss recent advances in the theory of quantitative homogenization which make it possible to analyze random walk with drift and other models in probability. Joint work with Scott Armstrong and Tuomo Kuusi.

For the past 25 years, a key player in contact topology has been the Floer-theoretic invariant called Legendrian contact homology. I'll discuss a package of new invariants for Legendrian knots and links that builds on Legendrian contact homology and is derived from rational symplectic field theory. This includes a Poisson bracket on Legendrian contact homology and a symplectic structure on augmentation varieties. Time permitting, I'll also describe an unexpected connection to cluster theory for a family of Legendrian links associated to positive braids. Parts of this are joint work in progress with Roger Casals, Honghao Gao, Linhui Shen, and Daping Weng.

We study the boundary layer theory for slightly viscous stationary flows forced by an imposed slip velocity at the boundary. According to the theory of Prandtl (1904) and Batchelor (1956), any Euler solution arising in this limit and consisting of a single "eddy" must have constant vorticity. Feynman and Lagerstrom (1956) gave a procedure to select the value of this vorticity by demanding a necessary condition for the existence of a periodic Prandtl boundary layer description. We will show that this condition is also sufficient for the existence of a periodic boundary layer described by the Prandtl equations. This is joint work with S. Iyer and T. Nguyen.

Consider the lattice Z^2, and assign length 1 or 2 to every edge by flipping a series of independent fair coins. This gives a random weighted graph, and looking at distances in this graph gives a random planar metric. This model is expected to have a continuum scaling limit as we decrease the spacing between lattice points. Moreover, most natural models of random planar metrics and random interface growth (the so-called `KPZ universality class') are expected to converge to the same limiting geometry. The goal of this talk is to introduce this limit, known as the directed landscape, and describe at least one model where we can actually prove convergence.

In this talk, I will present an overview of the framework originally proposed by Harder and further developed in collaboration with Raghuram to address rationality problems for special values of certain automorphic L-functions. I will then proceed to state my main results on the rationality of the special values of Langlands-Shahidi L-functions appearing in the constant term of the Eisenstein series associated with the exceptional group of type G_2​ over a totally imaginary number field. This study marks the first instance where rank-one Eisenstein cohomology is employed to investigate the arithmetic of automorphic L-functions in the presence of multiple L-functions.

Among the first significant results of algebraic topology is the computation, by Thom, Milnor, Novikov, and Wall among others, of the bordism groups of stably complex and oriented manifolds. After reviewing these results, I will discuss the notion of derived orbifolds, and briefly indicate how the bordism groups of these objects appear as universal recipients of invariants arising in Gromov-Witten theory and symplectic topology. Finally, I will state what is known about them, as well as some conjectures about the structure of these groups.

Dehn surgery is a fundamental construction in topology where one removes a neighborhood of a knot from the three-sphere and reglues to obtain a new three-manifold. The Cosmetic Surgery Conjecture predicts two different surgeries on the same knot always gives different three-manifolds. We discuss how gauge theory, in particular, the Chern-Simons functional, can help approach this problem. This technique allows us to solve the conjecture in essentially all but one case. This is joint work with Ali Daemi and Mike Miller Eismeier.

The directed landscape is a random directed metric on the plane that is the scaling limit for models in the KPZ universality class. In this metric, typical pairs of points are connected by a unique geodesic. However, certain exceptional pairs are connected by more exotic geodesic networks. The goal of this talk is to describe a full classification for these exceptional pairs. I will also discuss some connections with other models of random geometry.

Despite the impressive performance of rituximab (R) containing regimens like R-CHOP in CD20+ Non-Hodgkin’s Lymphoma (NHL), 30-60% of R-naïve NHL patients are estimated to be resistant, and approximately 60% of those patients will not respond to subsequent single agent R treatment. Given that antibody dependent cell mediated cytotoxicity (ADCC) and phagocytosis (ADCP) are thought to be the major mechanisms of action of Rituximab, increasing the activation levels of natural killer (NK) and macrophage (MP) cells may be one strategy for overcoming R resistance.

During (and after) the Fields Institute Industrial Problem Solving Workshop in August 2019, academic participants and industry mentors developed and calibrated to literature data a quantitative systems pharmacology (QSP) model of ADCC/ADCP to interrogate which mechanisms of R resistance could be overcome by increased NK or MP activation, and how much effector cell activation would be required to overcome a given degree and mechanism of R resistance.

This work was motivated by a real-world pharmaceutical drug development question, and the academic-industry interactions during and after the workshop resulted in sharknado plots as well as a published QSP model (presented at American Association of Cancer Research Annual Meeting, 2021) that was able to address some of the key questions around overcoming R resistance. The published model was then incorporated into an in-house QSP model supporting the development of a Takeda investigational drug which is being developed to restore R sensitivity in an R-resistant patient population.

Distance problems in discrete geometry include fascinating examples of questions that are easy to state and hard to solve. Three of the best known problems of this type, raised in the 40s, are the Erd\H{o}s Unit Distance Problem, his Distinct Distances Problem, and the Hadwiger-Nelson Problem about the chromatic number of the unit distance graph in the plane. I will describe surprisingly tight recent solutions of the analogs of all three problems for typical norms, settling, in a strong form, questions and conjectures of Matou\v{s}ek, of Brass, of Brass, Moser and Pach, and of Chilakamarri. I will also discuss a related work about ordering points according to the sum of their distances from chosen vantage points. The proofs combine Combinatorial, Geometric and Probabilistic methods with tools from Linear Algebra, Topology, and Algebraic Geometry. Based on recent joint works with Matija Buci\'c and Lisa Sauermann, and with Colin Defant, Noah Kravitz and Daniel Zhu.

The field of derivation of kinetic equations has seen many impressive advances recently. Yet the well-posedness and dynamics of these equations remain poorly understood. In this talk I will address such questions, and present a method to prove global existence, scattering and propagation of moments for inhomogeneous kinetic equations. It uses dispersive estimates for free transport, combined with kinetic theory techniques to deal with the specific difficulties brought by the structure of the equation under consideration (e.g. its cross section, the degree of the nonlinearity). I will discuss its concrete implementation for the kinetic wave and Boltzmann equations. This is based on joint work with Ioakeim Ampatzoglou.