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Sorin Mitran : Cytoskeleton multiscale model

One of the challenges in biology is relating biochemical reactions that occur at the protein nanoparticle size of 1-100 nm to large scale effects on the cell or tissue scale of 0.01-10 mm. The cytoskeleton is a remarkable example with actin polymerization/depolymerization leading to locomotion, metastasis or apoptosis. This talk presents a recently developed multiscale model that captures large-scale effects produced by changes in biochemical reactions. The model is a computational algorithm that determines effective continuum properties of a homogenized cytoskeleton model by concurrent microscopic simulation. Concepts from information theory and optimal transport are applied to link disparate scales in a computationally efficient manner. One of the interesting aspects of this approach is the combination of standard computational modeling techniques (finite volume, numerical stochastic ODEs) with statistical concepts and learning theory.

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