# Hau-tieng Wu : Medical challenges meet time series analysis and manifold learning

Adaptive acquisition of correct features from massive datasets is at the core of modern data analysis. One particular interest in medicine is the extraction of hidden dynamics from an observed time series composed of multiple oscillatory signals. The mathematical and statistical problems are made challenging by the structure of the signal which consists of non-sinusoidal oscillations with time varying amplitude and time varying frequency, and by the heteroscedastic nature of the noise. In this talk, I will discuss recent progress in solving this kind of problem. Based on the cepstrum-based nonlinear time-frequency analysis and manifold learning technique, a particular solution will be given along with its theoretical properties. I will also discuss the application of this method to two medical problems Â? (1) the extraction of a fetal ECG signal from a single lead maternal abdominal ECG signal; (2) the simultaneous extraction of the instantaneous heart rate and instantaneous respiratory rate from a PPG signal during exercise. If time permits, an extension to multiple-time series will be discussed.

**Category**: Applied Math and Analysis**Duration**: 01:14:44**Date**: February 24, 2017 at 11:55 AM**Views**: 108-
**Tags:**seminar, Applied Math And Analysis Seminar

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