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Daniel Lew : Modeling the effect of vesicle traffic on polarity establishment in yeast

There are two generally accepted models for the cell biological positive feedback loops that allow yeast cells to break symmetry and establish an axis of polarity. Both have been subjects of published mathematical analyses. Here I will argue that the models used to support a vesicle trafficking model incorporated a simplifying assumption that seemed innocuous but in fact was critical to their success. The assumption is not physically plausible, and its removal means that the model fails. I will show how changing other assumptions can make the model work, but there is no experimental support for those changes. And without them, the vesicle trafficking model perturbs polarity, rather than establishing polarity

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