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Victoria Booth : Dynamics of sleep-wake regulation

Sleep and wake states are regulated by the interactions among a number of
brainstem and hypothalamic neuronal populations and the expression of
their neurotransmitters. Based on experimental studies, several different
structures have been proposed for this sleep-wake regulatory network with
particular debate over components involved in rapid-eye movement (REM)
sleep regulation. We have developed a mathematical modeling framework
that is uniquely suited for investigating the structure and dynamics of
proposed sleep-wake regulatory networks. Using this framework, we are
analyzing the competing proposed network structures for the regulation of
REM sleep to determine how the structure of the sleep-wake regulatory
network determines sleep-wake behavior and the dynamics of behavioral
state transitions.

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