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Linda Petzold : The Emerging Roles and Computational Challenges of Stochasticity in Biological Systems


In recent years it has become increasingly clear that stochasticity plays
an important role in many biological processes. Examples include bistable
genetic switches, noise enhanced robustness of oscillations, and fluctuation
enhanced sensitivity or "stochastic focusing." Numerous cellular systems
rely on spatial stochastic noise for robust performance. We examine the
need for stochastic models, report on the state of the art of algorithms and
software for modeling and simulation of stochastic biochemical systems, and
identify some computational challenges.

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