Gas-solids chemically reacting flows are omnipresent in many multiphase flow reactors in various industries like Chemical, Fossil and Nuclear. The challenging aspect of modeling these reacting flows are the wide range of both temporal and spatial scales encountered in these systems. The challenge is to accurately account and bridge (as seamlessly as possible) the length and time scales involved in the problem. First, the problem is introduced using biomass gasifier/pyrolyser and nuclear fuel coater with sample results as examples and provide an overview of the various models currently used at the different scales. In particular, the critical role of the granular dynamics in the overall performance of the reactors will be highlighted. The ongoing development of a multiphysics and multiscale mathematics framework for coupling various modeling methods over a range of scales will be presented. The development of a general wavelet-based multiscale methodology called compound wavelet matrix (CWM) for bridging spatial and temporal scales will be reported. Finally, the steps needed to generalize the current methodology for arbitrary heterogeneous chemically reacting flows or other applications involving multiscale/multiphysics coupling will be elucidated. The challenges and opportunities of employing these models for rapid deployment of clean energy solutions based on multiphase flow reactors to the market place will be discussed.