Many problems that arise in mathematics, science, and engineering can be formulated as solving a parameterized system of polynomial equations which must be solved for given instances of the parameters. One way to solve these systems is to use a common technique within numerical algebraic geometry called homotopy continuation. My talk will start with background on homotopy continuation and parametrized polynomial systems, followed by applications to problems in computer vision and kinematics. Of these, I will first present a new approach which uses locally adaptive methods and sparse matrix calculations to solve parameterized overdetermined systems in projective space. Examples will be provided in 2D image reconstruction to compare the new methods with traditional approaches in numerical algebraic geometry. Second, I will discuss a new definition of monodromy action over the real numbers which encodes tiered characteristics regarding real solutions. Examples will be given to show the benefits of this definition over a naive extension of the monodromy group (over the complex numbers). In addition, an application in kinematics will be discussed to highlight the computational method and impact on calibration.