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Adriana Dawes : Protein localization at the single cell level: Interplay between biochemistry, mechanics and geometry

Cells are highly organized and complex structures, with the capacity to segregate specific factors to spatially disjoint regions in a process called polarization. Polarization, which specifies a spatial axis in the cell, is a highly conserved biological process and is required for proper embryonic development, wound healing, and many other normal and pathological biological functions. Despite the importance of polarization, we do not fully understand how this protein segregation is initiated and maintained. In this talk, I will show how we can use numerical and analytical approaches to investigate how symmetry breaking begins the process of polarization, and how the geometry of the cell may play a role in the establishment and maintenance of spatial patterns associated with polarization.

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