John Tyson : Irreversible Transitions, Bistability and Checkpoints in the Eukaryotic Cell Cycle (Feb 21, 2014 11:55 AM)

              "Perhaps a proper understanding of the complex
              regulatory networks making up cellular systems
              like the cell cycle will require a shift from common
              sense thinking...to a more abstract world, more
              readily analyzable in terms of mathematics."
              (Paul Nurse, Cell, 7 January 2000)

The cell cycle is a striking example of the necessity of systems-level
thinking in 21st century molecular cell biology. The resolute reductionism
of the last century, albeit necessary for identifying the molecular
components of cellular control systems and their interactions, has failed
to provide a comprehensive, integrative understanding of the molecular
basis of cell physiology. Putting the pieces back together requires new
ways of thinking about and doing molecular biology--an approach now
known as molecular systems biology. In this lecture I will show how
systems-level thinking reveals deep and unexpected principles of cell
cycle regulation.

• Category: Mathematical Biology
• Duration: 01:14:48
• Date:  February 21, 2014 at 11:55 AM
• Views: 113
• Tags:   seminar, Mathematical Biology Seminar