# Bo Li : Dielectric Boundary Force in Biomolecular Solvation

A dielectric boundary in a biomolecular system is a solute-solvent (e.g., protein-water) interface that defines the dielectric coefficient to be one value in the solute region and another in solvent. The inhomogeneous dielectric medium gives rise to the dielectric boundary force that is crucial to the biomolecular conformation and dynamics. This talk begins with a review of the Poisson-Boltzmann theory commonly used for electrostatic interactions in biomolecular interactions and then focuses on the mathematical description of dielectric boundary force. A precise definition and explicit formula of such force are presented. The motion of a cylindrical dielectric boundary driven by the competition between the dielectric boundary force and the reduction of surface energy is then studied. Implications of the mathematical findings to biomolecular conformational stabilities are discussed.

**Category**: Applied Math and Analysis**Duration**: 01:34:47**Date**: August 26, 2013 at 11:55 AM**Views**: 125-
**Tags:**seminar, Applied Math And Analysis Seminar

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