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# Jasmine Foo : Modeling diversity in tumor populations and implications for drug resistance

In this talk I will discuss a branching process model developed to study intra-tumor diversity (i.e. the variation amongst the cells within a single tumor). This variation arises due to heritable (epi)genetic alterations which can confer changes in cellular fitness and drug response. In the asymptotic (t-> infinity) regime, we study the growth rates of the population as well as some ecological measures of diversity in the tumor. In the second half of the talk I will discuss applications of this model to studying the emergence of drug resistant populations in Chronic Myeloid Leukemia (CML). (Joint work w/K. Leder, J. Mayberry, R. Durrett, F. Michor)

**Category**: Probability**Duration**: 01:34:51**Date**: January 20, 2011 at 4:10 PM**Views**: 115-
**Tags:**seminar, Probability Seminar

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