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Gregory Herschlag : A mechanochemical model for auto-regulation of lung airway surface liquid volume (Sep 6, 2013 11:55 AM)

I will present a proof-of-principle model for auto-regulation of liquid volume in the lung airway surface layer (ASL). The model couples biochemical kinetics, transient ASL volume, and homeostatic mechanical stresses. The work is based on the hypothesis that ASL volume is sensed through soluble mediators and phasic stresses generated by beating cilia and global percussive and air drag forces. Simulations demonstrate that homeostatic volume regulation is a natural consequence of the model and the underlying hypotheses. The model successfully reproduces many experimental results and passes qualitative sensitivity tests. These results compel an advanced airway hydration model in which detailed kinetics of multiple molecular pathways, feedback to ASL viscoelasticity properties, and stress signaling from the ASL to the cilia and epithelial cells are taken into account.

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